In reverse order
Just out, and open access, in the Journal of Pain Research:
This seems like an important paper – building some foundations of empirical human findings under some theoretical castles in the air.
The paper impresses if taken in reverse order – Statistical considerations are given a transparent airing and the Study limitations section is detailed and fleshed out. Adding further to the sense that this is good science is a discussion on causality. Rather than committing the logical mistake of making unwarranted strong causal claims, the authors propose a number of possibilities and don’t shy away from the complexity.
To the findings
“… we found evidence of both neuroinflammation (as assessed in CSF) and chronic systemic inflammation (as assessed in plasma). Two groups of proteins (one for CSF and one for plasma) highly discriminating between patients and controls are presented. Notably, we found high levels of CSF chemokine CX3CL1 (also known as fractalkine). In addition, previous findings concerning IL-8 in FM were replicated, in both CSF and plasma. This is the first time that such an extensive inflammatory profile has been described for FM patients. Hence, FM seems to be characterized by objective biochemical alterations, and the lingering characterization of its mechanisms as essentially idiopathic or even psychogenic should be seen as definitively outdated.” (emphasis added)
A strong closing statement.
Others have been saying it for a long time, but perhaps the (very real) experience and suffering of those who have been labelled with Fibromyalgia have nothing to do with taut bands, fascial restrictions and those 18 (or 11) infamous trigger points…
– Tim Cocks